48; p less then 0.001) and tweets (2013, 1.84; 2015, 6.68; 2017, 27.8; p less then 0.001), reaching a larger readership via Twitter (2013, 4,210; 2015, 19,300; 2017, 66,800; p less then 0.001). Log-transformed Altmetric scores were correlated with log-transformed citations for articles published in 2017 (rs=0.40; p=0.02). On multivariable analysis, tweets (OR 1.27 [95%CI 1.01-1.61]; p=0.044) and mentions by news outlets (OR 30.49 [95%CI 4.03-230.16]; p=0.001) were predictive of high Altmetric scores. Conclusions This longitudinal analysis demonstrates that social media attention related to top performing articles has increased in recent years. Social media is an effective tool to increase article reach and knowledge translation, with Altmetric scores that correlated with citations.Decision making for univentricular or anatomical repair remains challenging in children with borderline left ventricle. The unpredictable outcomes have led many caregivers to pursue single ventricle strategy. We describe two cases of patients with borderline left ventricle initially palliated with univentricular strategy followed by very late conversion to anatomical repair 4 and 16 years later. Anatomical conversion should be considered for these patients even many years later. During the first palliation stages, hemodynamic conditions preserving the potential for growth of the LV should be maintained.Background Contradictory findings from randomized trials addressing similar research questions are not uncommon in medicine. While differing results may reflect true differences in the treatment effects or in the deliverability of the intervention, more commonly it is as a consequence of small but important discrepancies in study design. Methods The writing group selected four recent trials with apparently contradictory results (two on revascularization for left main coronary stenosis and two on treatment of secondary mitral regurgitation). Detailed methodological analysis was performed to elucidate the difference in findings. Results Differences in the definition of the primary outcome are the most likely explanation for the contradictory findings of NOBLE vs EXCEL. Differences in study design (leading to substantially different patient populations) as well as differences in outcome definition might explain the discrepant findings of MITRA-FR vs COAPT. https://www.selleckchem.com/products/fasoracetam-ns-105.html Conclusions As shown by the comparative analysis of NOBLE and EXCEL and MITRA-FR and COAPT, changes in study design, outcome definitions and patient population can markedly affect the outcome of randomized clinical trials.Dysregulated transcription factors (TFs) fuel aberrant gene expression networks, resulting in cell overproliferation, migration, and immunosuppression. Given that TFs are regarded to have vital roles in tumors, various approaches are exploited to modulate their activities. Nevertheless, except for some ligand-binding nuclear receptors, most TFs are still considered 'undruggable' targets. Responding to extra- or intracellular stimuli, TFs are decorated with an array of post-translational modifications (PTMs) to regulate their subcellular localizations, protein-protein/DNA interactions, and stability. These PTMs orchestrate the multiple functions of TFs, thus offering numerous potential targets. In this review, we systematically review emerging concepts and effective agents in PTMs-associated TF-targeting, which could provide paradigms for cancer treatment.Research question Is the spatiotemporal phenomenology of the cytoplasmic halo during fertilization related to embryonic competence? Design Time-lapse images from 1009 zygotes were retrospectively analysed from 560 patients who underwent IVF with minimal stimulation and single vitrified-warmed blastocyst transfer between April 2017 and March 2018. Halo presence and morphokinetics were monitored and compared relative to embryo quality, blastocyst expansion and ongoing pregnancy. Results Halo was observed in 88% of fertilized oocytes. Embryos derived from zygotes without halo had significantly higher rates of rapid cleavage (P = 0.0004), cell fusion (P = 0.0028) and asymmetrical division (P = 0.0002) compared with those derived from zygotes with halo. Multivariate logistic regression analysis had significantly higher developmental rates compared with the expanded blastocyst stage in embryos displaying a halo, regardless of its distribution (adjusted odds ratio 0.435; P = 0.0004). Prolonged halo time intervals were significantly correlated with increased asymmetrical division at first cell division (P = 0.0412, P = 0.0088, respectively) and decreased developmental rates to expanded blastocyst stage (P = 0.0062, P = 0.0020, respectively). Additionally, prolonged presence of the cytoplasmic halo was associated with a decreased ongoing pregnancy rate (adjusted odds ratio 0.871; P = 0.006). Poor sperm quality and decreased oocyte diameter were correlated with absence of the cytoplasmic halo (P = 0.0477, P less then 0.0001, respectively) or prolonged halo presence (P = 0.0139, P = 0.0002, respectively). Conclusions Halo presence and morphokinetics are associated with cleavage patterns, development to blastocyst stage and ongoing pregnancy rate after single blastocyst transfer. Halo morphokinetics seems to reflect sperm and oocyte quality. Cytoplasmic halo might be valuable predictor for refining selection of more developmentally competent blastocysts.Research question What are the main risk factors associated with ectopic pregnancy and what is the true incidence of ectopic pregnancies in an IVF programme? Design Retrospective single-centre study of 12,429 blastocyst transfers (8182 fresh and 4247 frozen embryo transfers) conducted between January 2010 and December 2017. IVF outcome was analysed, and ectopic pregnancy risk evaluated according to patient's characteristics and assisted reproductive technology treatment factors. Results Of 5061 patients reporting a positive pregnancy test, 43 were diagnosed with ectopic pregnancy (0.85%). Neither female age (36.7 versus 35.8 years), body mass index, quality of transfer nor stimulation protocol affected the ectopic pregnancy rate, but history of previous ectopic pregnancy (OR 3.26; P = 0.0080), tubal surgery, or both (OR 6.20; P less then 0.0001) did. The incidence of ectopic pregnancy was increased in women with uterine malformations (OR 3.85; P = 0.0052), uterine pathologies (OR 5.35; P = 0.0001), uterine surgeries (OR 2.